• An up-to-date account of many contemporary aspects of iminosugars from organic synthesis to clinical studies
  • Features contributions by the major world experts in the field
  • Features a table correlating the structures of more than 600 iminosugars with their biological activities

"Although the first 13 chapters by themselves would stand alone as an excellent 326-page book, what really makes this book stand out is the 14th chapter. These last 130 pages of the book are composed of a detailed and well-referenced table of iminosugar compounds organized by structural class and therapeutic indications. [...] it is the final chapter that makes this book a must buy."

G. A. O'Doherty, J. Am. Chem. Soc. 2008, 130, 6651.

"...an excellent review of many aspects of iminosugars. [...] This monograph should be a valuable tool for the development of new powerful inhibitors based on iminosugars."

K. Krämer, Angew. Chem. Int. Ed. 2008, 47, 9378.

"Given the recent resurgence of interest in this class of compounds, the text is a welcome review of the area."

C. N. Filer, J. Med. Chem. 2008, 51, 2868.

Iminosugars were first imagined and synthesized by chemists in the 60's before being isolated from Nature a few years later. Since the discovery of their biological activity as potent glycosidase inhibitors in the 70's, iminosugars have been the subject of intense studies at the interface between organic synthesis, glycobiology and medicinal science. Regarding the impressive series of discoveries in the field over the past ten years, it can confidently be said that we are witnessing "a boom time" for iminosugar chemistry and biology! The aim of this book is to present the multifaceted aspects of iminosugars from structure to biological activities and from synthesis to therapeutic applications. Chapter 2 focus on naturally occurring iminosugars. Chapter 3 is devoted to recent synthetic strategies and combinatorial approaches towards iminosugar libraries. Important classes of iminosugars and their biological activities are presented in Chapter 4 (imino-C-glycosides), chapter 5 (imino-C-disaccharides), chapter 6 (isoiminosugars, i. e. 1-aza carbasugars) and chapter 8 (iminosugar C-nucleosides). Chapter 7 deals with recent developments in the field of glycosyltransferase inhibitors. Moving closer to therapeutic applications, chapters 9 and 12 are devoted to iminosugars as antiviral and antitumor agents respectively. The two main strategies for the chemotherapeutic treatment of lysosomal diseases are reviewed in Chapter 10 (Substrate Reduction Therapy) and chapter 11 (Chaperon Therapy). Chapter 13 is an overview of the medicinal use of iminosugars, including key reflections on their therapeutic potential. Finally, chapter 14 provides tables which correlate the structure of more than 600 iminosugars of therapeutic interest with their biological activities. Compounds have been selected for their potential as therapeutic agents. The goal of this at-a-glance table is to facilitate and to stimulate further research in the area of iminosugar by relating structure to properties.